Postbiotic+ – The Gut Game-Changer You’ve Been Waiting For!

At Silver Fern™, we don’t just keep up with science — we like to stay ahead of it, which is why we didn’t launch a butyrate product until we found BIOMend™!

Butyrate is a superstar nutrient with a list of benefits so long it could make your head spin. Science is practically bursting with studies about what it can do! We’ve looked closely at the two main types of butyrate out there, tributyrin and sodium butyrate, but they just didn’t perform like we needed them to. Now there is a third option, arguably the best and most bioavailable butyrate ingredient available: BIOMend™’s L-lysine butyrate.^*

With BIOMend™’s new form of butyrate, we created what we believe is the best, most advanced postbiotic product on the market, enhanced with Beta Via™ and Immuse® to deliver gut and immune health like never before. Because as we’ve learned over the past few years, who doesn’t need a boost to our gut and immune health?

Got gut health concerns? Postbiotic+ could be your new best friend.^* Sluggish metabolism? Postbiotic+ might help fine-tune your cellular metabolism to operate at peak performance.^* Postbiotic+ isn’t just about the research studies, it’s about RESULTS.

Ready to give your body the ultimate tune-up?

Meet Postbiotic+, your secret weapon for feeling and functioning at your best. Packed with bioavailable butyrate, this powerhouse supplement fuels your colon cells, protects your gut barrier, and may amp up metabolic and immune function. But the benefits don’t stop there, ingredients in Postbiotic+ also have a hand in supporting brain health^{^} and exercise performance.

What Does Postbiotic+ Do?

1. Gut and Immune Health:

Postbiotic+ offers a comprehensive gut health boost by addressing both the structural and immune aspects of your GI system. It’s like a bodyguard for your immune system, strengthening its' defenses while keeping it balanced. This means it is ready to fight when it needs to, without going overreactive.^* If you have struggled with immune imbalances or intolerances, this dual-action approach to boosting gut health and immune health supports a healthier, more robust and balanced immune and digestive system. Think of it as a one-two punch for optimal gut and immune health!

2. Metabolic Health:

BIOMend™, the powerhouse butyrate ingredient in Postbiotic+, is a hero for cellular metabolism. Butyrate has been shown to improve insulin sensitivity^{^} and regulate glucose metabolism.^{*^} It also supports efficient energy use and metabolic health,^ which could be a game changer for those struggling with both!^* Long story short—it supports your metabolic function and keeps your energy on track!

3. Full Body Support:

Postbiotic+ was designed to support the whole body. Imagine imbalances spreading through your body, causing chaos like a wildfire. What you need are elite firefighters, the ingredients found in Postbiotic+, to move in and put out the “flames” and rebalance your body. Postbiotic+ helps your body stop the “fire” and return to its' best self. The body is truly amazing and with the right support it can rebalance like a champ!

What is in Postbiotic+?

BIOMend™

BIOMend™ is an advanced butyrate supplement designed to provide enhanced absorption and bioavailability over traditional butyrate. The improved bioavailability of BIOMend™ butyrate means more of the butyrate is absorbed and available to be utilized effectively in the body, allowing for more consistent systemic effects.^*

Key Supported Benefits:

• Supports the immune system^*
• Helps the gut barrier^*
• Helps with healthy immune system responses^*
• Helps fuel cellular metabolism^*
• May support insulin and leptin sensitivity^{*^}
• May support cognitive benefits^{*^}
• May help modulate appetite^{*^}

The Science Behind BIOMend™^{^}

• Regulation of Immune Response: Butyrate encourages the development of regulatory T-cells (Tregs), which help prevent excessive immune responses.^{^} This immune modulation can help in rebalancing many aspects of the immune system and may even help reduce certain reactions.^{*^}
• Enhanced Intestinal Barrier Function: Butyrate strengthens the epithelial barrier of the gut by stimulating the production of mucin and tight junction proteins.^{^} This may prevent “foreign invaders” and “bad stuff” from leaking into the bloodstream (leaky gut).* By improving gut integrity, butyrate helps with “fires” or imbalances in the system, since a leaky gut can contribute to imbalances in distant organs.^*
• Support for Epithelial Cell Health: Butyrate serves as a primary energy source for colonocytes (cells in the lining of the colon), which contributes to a healthy gut lining and efficient nutrient absorption.^*
• Insulin Sensitivity^{^} and Metabolic Health: Butyrate may enhance insulin sensitivity by modulating pathways in the liver and adipose tissue,^{^} which can help support a healthy metabolism.^*
• Energy Regulation: Butyrate plays a role in mitochondrial function, increasing fatty acid oxidation and promoting efficient energy usage, which can improve overall metabolic rate and reduce fat accumulation.^{*^}
• Blood-Brain Barrier Support: Butyrate is known to cross the blood-brain barrier, where it can exert its many benefits on brain and metabolic health.^{*^}
• Cognitive Benefits: Butyrate has been shown to increase brain-derived neurotrophic factor (BDNF)^{^}, which supports neuronal growth and cognitive health. It also appears to act as a histone deacetylase (HDAC) inhibitor^{^}, influencing gene expression in ways that may promote resilience to stress.^{*^}
• Epigenetic Modulation: As an HDAC inhibitor, butyrate may influence gene expression in beneficial ways, promoting effects on the immune system, cardiovascular system and metabolic health.^{*^}

BetaVia™ Pure

BetaVia™ Pure is derived from the algae Euglena gracilis that is rich in beta 1,3 glucans, and known for their immune-supporting properties. It is Beta Via™’s most concentrated form with greater than 95% beta 1,3 glucans, offering the highest purity.^*

Key Benefits:

• Immune System Support: BetaVia™ primes key immune cells, enhancing the body's natural defenses and supporting year-round immune health.^*
• Digestive Health: BetaVia™ contributes to overall digestive well-being by promoting a healthy gut microbiome and supporting intestinal barrier integrity.^*
• Respiratory Health: Clinical studies have shown that BetaVia™ can reduce the severity and duration of upper respiratory discomforts, supporting respiratory health.^*

The Science Behind BetaVia™ Pure^{^}

BetaVia™ operates through a triple-action mechanism:

1. Priming Innate Immune Cells: Beta 1,3 glucans in BetaVia™ are recognized by innate immune cells in the small intestine, leading to the activation and recruitment of these cells, which enhances both local and systemic immune responses.^*
2. Shaping the Microbiome: BetaVia™ interacts with gut microbiota, promoting the growth of beneficial bacteria and contributing to a balanced and healthy gut environment.^*
3. Protecting Intestinal Barrier Integrity: By supporting the health and function of the intestinal barrier, BetaVia™ helps regulate the interaction between the body and the environment, acting as a gatekeeper for what stays "in" and "out" of the body.^*

BetaVia™ offers a natural and clinically studied approach to enhancing immune, digestive, and respiratory health.^*

Immuse®

IMMUSE™ is a novel postbiotic ingredient derived from a patented strain of Lactococcus lactis known as LC-Plasma. Unlike traditional probiotics, which consist of live bacteria, IMMUSE™ is a heat-treated, non-viable bacterial strain, classifying it as a postbiotic.

Key Benefits:

• Comprehensive Immune Support: IMMUSE™ provides broad-spectrum support for the immune system through the activation of key immune cells, plasmacytoid dendritic cells (pDCs)^{^*}, that rapidly stimulate and recruit multiple immune cell types to defend and protect the body from foreign invaders.*^*
• Respiratory Health: Clinical studies have shown that Immuse® can reduce the severity and duration of upper respiratory discomforts, supporting respiratory health.*^*
• Exercise Performance: Provides immune support during exercise and may reduce fatigue associated with exercise.*^*

The Science Behind Immuse™^{^}

IMMUSE™ uniquely activates pDCs, a rare subset of immune cells that play a pivotal role in orchestrating both innate and adaptive immune responses.^{^} By activating pDCs, IMMUSE™ orchestrates a cascade effect, recruiting various other immune cells, including natural killer (NK) cells, T cells, and B cells.^{^} This comprehensive recruitment and activation enhances the body's overall immune defense mechanisms.^{*^}

IMMUSE™ offers a scientifically validated approach to enhancing immune function by targeting and orchestrating key immune cells, thereby providing comprehensive support for the body's natural defense systems.^*

Dosing and Expectations^#

Please dose according to the severity of the issues you’re experiencing. If in doubt, we recommend starting at the lower level and moving up as needed.

Mild Issues: 1 Pouch per month

• 1 stick with any meal during the day, best taken 30 to 60 minutes before your meal^#

Moderate Issues: 2 Pouches per month

• 1 stick with your first meal of the day and 1 stick with your last meal of the day, best taken 30 to 60 minutes before each meal^#

Severe Issues: 4 Pouches per month

• 2 sticks with your first meal of the day and 2 sticks with your last meal of the day, best taken 30 to 60 minutes before each meal^#

What to Expect:

Changes take time! Most start to notice benefits in six to eight weeks, with major noticeable changes at about 12 weeks.^*

When gut ingredients are effective and taken at clinical doses, one may experience some discomfort as your body is adjusting. While rare, if this occurs, please consider reducing the dosage by 50% for two weeks. Continue using the product at this adjusted level, and gradually increase back to the full dose as you are able. If discomfort continues, please stop taking immediately and consult with your medical professional.

Helpful Points to Consider:^#

1. Please do not exceed 2 sticks at one time.^#
2. Yes, you can start taking Postbiotic+ at any time of any protocol and with any of our products.
3. Please be aware that Postbiotic+ may have a direct and immediate impact on the gut-brain axis. Please be cautious when pairing it with nootropics and other cognition products.^*#
4. We are unaware of Postbiotic+ having any interactions with prescription medications, but please consult with your medical doctor prior to use.